Tau-441, V248L Mutant
Product background: The Tau proteins are a family of neuronal microtubule associated proteins that are found in the neurofibrillary tangles often associated with Alzheimer’s Disease. Tau promotes the assembly and maintains the structure of microtubules in neuronal cells.
About the product: Tau-441 is the mature human Tau isoform with 441 amino acids with the mutation V248L, and a mass of 46kDa. Expressed recombinantly in E. coli, Tau-441 is purified to our highest standards to ensure batch to batch consistency in both purity and quality.
Applications: rPeptide Tau products can be used for a wide variety of applications including aggregation studies, assay development, fibrillization, and as standards in customer analyses.
$300.00
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Product Details
- Size: 50 µg
- Physical State: White lyophilized powder
- Temperature Storage: -20°C
- Temperature Shipping: Ambient
- Sequence:MAEPRQEFEV MEDHAGTYGL GDRKDQGGYT MHQDQEGDTD AGLKESPLQT PTEDGSEEPG SETSDAKSTP TAEDVTAPLV DEGAPGKQAA AQPHTEIPEG TTAEEAGIGD TPSLEDEAAG HVTQARMVSK SKDGTGSDDK KAKGADGKTK IATPRGAAPP GQKGQANATR IPAKTPPAPK TPPSSGEPPK SGDRSGYSSP GSPGTPGSRS RTPSLPTPPT REPKKVAVVR TPPKSPSSAK SRLQTAPLPM PDLKNVKSKI GSTENLKHQP GGGKVQIINK KLDLSNVQSK CGSKDNIKHV PGGGSVQIVY KPVDLSKVTS KCGSLGNIHH KPGGGQVEVK SEKLDFKDRV QSKIGSLDNI THVPGGGNKK IETHKLTFRE NAKAKTDHGA EIVYKSPVVS GDTSPRHLSN VSSTGSIDMV DSPQLATLAD EVSASLAKQG L
- Source: Recombinant, in E. coli. No his-tag.
- Purity: >90% by SDS-PAGE
- Molecular Mass: 45,920 Da theoretical
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References
1. Avila, J., et al., (2004) Physiol Rev., 84 : 361
2. Goedert, M., (1993) Trends Neurosci., 16 : 460
3. Mandelkow, E., et al., (1996) Ann N Y Acad Sci., 777 : 96
4. Goedert, M., et al., (1989) Neuron., 3 : 519
5. Himmler, et al., (1989) Mol Cell Biol., 9 : 1381
6. Tai, C., et al., (2020) Neuron., 106(3) : 421-437.e11
7. Nobuhara, C., et al., (2017) Am J Pathol., 187(6) : 1399–1412 -
Publications
On-chip microtubule gliding assay for parallel measurement of tau protein species.
Lab Chip; doi: 10.1039/c5lc01486g.
