Tau Starter Kit

Tau is a family of major neuronal microtubule associated proteins that are found in the neurofibrillary tangles (NFT) in Alzheimer’s disease. Tau promotes the assembly and maintains the structure of microtubules in neuronal cells. The Tau proteins are derived from alternative mRNA splice variants that originate from a single gene and result in mature proteins that vary in size from 352 to 441 amino acids (36.8 to 45.9 kDa). There are six Tau isoforms, that differ from one another in having three or four microtubule binding repeats (R) of 31-32 amino acids each, and two, one or none amino terminal inserts (N) of 29 amino acids each. While the fetal brain contains a single isoform of tau (Tau-352) the adult brain has several isoforms all derived from a single gene by alternative mRNA splicing.

Catalog ID: T-1170

$1,100.00 – $1,850.00

Download Datasheet

  • Product Details
    • Physical State: White lyophilized powder
    • Temperature Storage: -20°C
    • Temperature Shipping: Ambient
    • Source: Recombinant. DNA sequences encoding the human tau isoforms were expressed in E. coli. No his-tag. Contains one each of: T-1001, T-1002, T-1003, T-1004, T-1005, T-1006
    • Purity: >90% by SDS-PAGE
    • Molecular Mass: 45,900; 42,600; 42,900; 39,700; 40,000; 36,800 theoretical

  • References

    1. Avila, J., et al., (2004) Physiol Rev., 84 : 361
    2. Goedert, M., (1993) Trends Neurosci., 16 : 460
    3. Mandelkow, E., et al., (1996) Ann N Y Acad Sci., 777 : 96
    4. Goedert, M., et al., (1989) Neuron., 3 : 519
    5. Himmler, et al., (1989) Mol Cell Biol., 9 : 1381
    6. Tai, C., et al., (2020) Neuron., 106(3) : 421-437.e11
    7. Nobuhara, C., et al., (2017) Am J Pathol., 187(6) : 1399–1412

Related products