Vorinostat
Potent and selective histone deacetylase inhibitor 1. Induces apoptosis in a variety of tumor cell lines (IC50 = 3-8 μM) 2. Synergizes with kinase inhibitors to kill CNS tumor cells 3. Prevents diabetes in a mouse model by immunoregulation and -cell protection 4. Induces neuronal differentiation in DKFZ-EP1NS cells, a cell line which displays stem cell features such as self-renewal capacity 5. Cell permeable.
$95.00 – $410.00
-
Product Details
- Physical State: White powder
- Temperature Storage: -20°C
- Temperature Shipping: Ambient
- Molecular Mass: 264.3
-
References
1. Vrana, A., et al., (1999) Oncogene, 18 : 7016
2. Butler, L.M., et al., (2002) Proc. Natl. Acad. Sci. USA, 99 : 11700
3. Tang, Y., et al., (2012) Cancer Biol. Ther., 13 : 567
4. Christensen, D.P., et al., (2014) Proc. Natl. Acad. Sci. USA, 111 : 1055
5. Milde, T., et al., (2011) Acta. Neuropathol., 122 : 637
