Publications

Technical performance of a novel, fully automated electrochemiluminescence immunoassay for the quantitation of β-amyloid (1–42) in human cerebrospinal fluid.

Alzheimer’s & Dementia; doi: 10.1016/j.jalz.2015.09.009..

Stabilization of native amyloid β-protein oligomers by Copper and Hydrogen peroxide Induced Cross-linking of Unmodified Proteins (CHICUP).

Biochim Biophys Acta; doi: 10.1016/j.bbapap.2015.12.001.

Bis-pyridylethenyl benzene as novel backbone for amyloid-β binding compounds. Science Direct; doi:10.1016/j.bmc.2016.05.022. Rob J.A. Nabuurs, Varsha V. Kapoerchan, Athanasios Metaxas, Sarah Hafith, Maaike de Backer, Mick M. Welling, Wim Jiskoot, Adrianus M.C.H. van den Nieuwendijk, Albert D. Windhorst, Herman S. Overkleeft, Mark A. van Buchem, Mark Overhand, Louise van der Weerd (2016)

Methods of Treating Alzheimer's Disease and Other Tauopathies with Inhibitors of Microtubule Affinity Regulating Kinase

Free Patents Online; United States Patent Application 20160030510.

Effect of Copper and Zinc on the Single Molecule Self-Affinity of Alzheimer’s Amyloid-β Peptides.

PLOS ONE; doi: 10.1371/journal.pone.0147488..

Reference measurement procedure for CSF amyloid beta (Aβ)1-42 and the CSF Aβ1-42 /Aβ1-40 ratio - a cross-validation study against amyloid PET.

Journal of Neurochem.; doi: 10.1111/jnc.13838..

Ste24p Mediates Proteolysis of Both Isoprenylated and Non-prenylated Oligopeptides.

Journal of Biological Chemistry; doi: 10.1074/jbc.M116.718197.

Biophysical Insights into the Role of Amyloid-Beta Misfolding in Alzheimer’s Disease Pathogenesis

deepblue.lib; doi: 10.1038/srep11811.

Comparison of the amyloid pore forming properties of rat and human Alzheimer’s beta-amyloid peptide 1-42: Calcium imaging data.

Data Brief; doi: 10.1016/j.dib.2016.01.019.

Effect of IVIG Formulation on IgG Binding to Self- and Exo- Antigens In Vitro and In Vivo

PLOS ONE; http://dx.doi.org/10.1371/journal.pone.0161826.

Assessment of an Initial Roadmap for Protein-Protein-Small Molecule Networks in the Brain of Alzheimer’s Disease

deepblue.lib; .

Amyloid-b peptides act as allosteric modulators of cholinergic signalling through formation of soluble BA b ACs.

Brain; doi: 10.1093/brain/awv318..

Quantitative analysis of amyloid polymorphism using height histograms to correct for tip convolution effects in atomic force microscopy imaging.

RSC Advances; DOI:10.1039/C6RA24031C.

Characterization of a novel adult murine immortalized microglial cell line and its activation by amyloid-beta

BioMed Central; DOI: 10.1186/s12974-016-0484-z.

Structural insights into mechanisms for inhibiting amyloid β42 aggregation by non-catechol-type flavonoids. https://doi.org/10.1016/j.bmc.2015.12.021

Bioorg Med Chem; doi: 10.1016/j.bmc.2015.12.021.

The Alzheimer's-related amyloid beta peptide is internalised by R28 neuroretinal cells and disrupts the microtubule associated protein 2 (MAP-2)

Science Direct; http://dx.doi.org/10.1016/j.exer.2016.10.013.

A theranostic agent for in vivo near-infrared imaging of β-amyloid species and inhibition of β-amyloid aggregation.

Biomaterials; doi: 10.1016/j.biomaterials.2016.03.047.

Presynaptic dystrophic neurites surrounding amyloid plaques are sites of microtubule disruption, BACE1 elevation, and increased Aβ generation in Alzheimer’s disease.

Acta Neuropathologica; doi: 10.1007/s00401-016-1558-9.

The Luminescent Oligothiophene p-FTAA Converts Toxic Aβ1–42 Species into Nontoxic Amyloid Fibers with Altered Properties.

Journal of Biological Chemistry; doi: 10.1074/jbc.M115.696229..

PHARMACEUTICAL COMPOSITION FOR TREATING OR PREVENTING DEGENERATIVE BRAIN DISEASE COMPRISING MULTI-TARGETING COMPOUNDS

freepatentsonline; .