Publications

Single-domain antibody–based noninvasive in vivo imaging of α-synuclein or tau pathology

Science Advances (2023) 9 (19), eadf3775 DOI: 10.1126/sciadv.adf3775

Pharmacologic inhibition of NLRP3 reduces the levels of α-synuclein and protects dopaminergic neurons in a model of Parkinson's disease

Journal of Neuroinflammation  (2023) 20 (1), 147 DOI: 10.1186/s12974-023-02830-w

Evolving prion-like tau conformers differentially alter postsynaptic proteins in neurons inoculated with distinct isolates of Alzheimer’s disease tau

Cell & Bioscience (2023) 13 (1), 174 DOI: 10.1186/s13578-023-01133-0

Endolysosomal impairment by binding of amyloid beta or MAPT/Tau to V-ATPase and rescue via the HYAL-CD44 axis in Alzheimer disease

Autophagy (2023) 19 (8), 2318-2337 DOI: 10.1080/15548627.2023.2181614

Brain-derived tau: a novel blood-based biomarker for Alzheimer's disease-type neurodegeneration

Brain (2023) 146 (3), 1152-1165 DOI: 10.1093/brain/awac407

A Hairpin Motif in the Amyloid-β Peptide Is Important for Formation of Disease-Related Oligomers

Journal of the American Chemical Society (2023) 145 (33), 18340-18354 DOI: 10.1021/jacs.3c03980

Border-associated macrophages promote cerebral amyloid angiopathy and cognitive impairment through vascular oxidative stress

Molecular Neurodegeneration (2023) 18 (1), 73 DOI: 10.1186/s13024-023-00660-1

Mutations in α-synuclein, TDP-43 and tau prolong protein half-life through diminished degradation by lysosomal proteases

Molecular Degeneration(2023) 18 (1), 29 DOI: 10.1186/s13024-023-00621-8

Amyloid fibril proteomics of AD brains reveals modifiers of aggregation and toxicity

Molecular Neurodegeneration (2023) 18 (1), 61 DOI: 10.1186/s13024-023-00654-z

An astrocyte BMAL1-BAG3 axis protects against alpha-synuclein and tau pathology

Neuron (2023) 111 (15), 2383-2398.e7 DOI: 10.1016/j.neuron.2023.05.006

Genipin prevents alpha-synuclein aggregation and toxicity by affecting endocytosis, metabolism and lipid storage

Nature Communications (2023) 14 (1), 1918 DOI: 10.1038/s41467-023-37561-2

Microglial REV-ERBα regulates inflammation and lipid droplet formation to drive tauopathy in male mice

Nature Communications (2023) 14 (1), 5197 DOI: 10.1038/s41467-023-40927-1

Relationship of serum beta-synuclein with blood biomarkers and brain atrophy

Alzheimers & Dementia (2023) 19 (4), 1358-1371 DOI: 10.1002/alz.12790

Development of an α-synuclein positron emission tomography tracer for imaging synucleinopathies

Cell (2023) 186 (16), 3350-3367.e19 DOI: 10.1016/j.cell.2023.06.004

Human Microglial State Dynamics in Alzheimer’s Disease Progression

Cell; http://dx.doi.org/10.1016/j.cell.2023.08.037

Blocking microglial activation of reactive astrocytes is neuroprotective in models of Alzheimer’s disease

Scientific Reports; https://doi.org/10.1186/s40478-021-01180-z

Engagement of TREM2 by a novel monoclonal antibody induces activation of microglia and improves cognitive function in Alzheimer’s disease models

Imipramine and olanzapine block apoE4-catalyzed polymerization of Aβ and show evidence of improving Alzheimer’s disease cognition

bioRxiv; https://doi.org/10.1101/2021.03.28.437389

Heterotypic Aβ interactions facilitate amyloid assembly and modify amyloid structure

bioRxiv; https://doi.org/10.1101/2021.04.28.441786

Serotonin Promotes Serum Albumin Interaction with the Monomeric Amyloid β Peptide

International Journal of Molecular Sciences; https://doi.org/10.3390/ijms22115896